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episode of faulting. They probably originate in magmatically associated brines. In backarc basins that form above oceanic subduction zones the crust is similar to oceanic, although generated in a different fashion, and so mineral deposits would not be expected to differ greatly from those in oceanic crust. The mineralization in these settings may be similar to that formed during the early development of a spreading ridge, and thus may be related to magmatic and exhalative volcanic processes. Zones of continental collision and terrane accretion (Sections 10.4, 10.6) also host a wide range of metalliferous deposits. These belts may display allochthonous terranes containing mineral associations that formed during the early stages of crustal accretion, such as ophiolites, ferromanganese nodules, subduction-related deposits, and mineralization related to the early stages of rifting. Deposits that originate during the continental

Part VII: Appendixes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 677

If a product a traditional drug in a clinical trial works in 20 percent of subjects, and the control works in 10 percent, you need a large study, carefully designed, to capture that small difference in benefit But if a product works in 90 percent which, in theory, a targeted drug could do you re going to see that in a very small trial And if it s targeted to work on a very specific pathway that s relevant to your disease, by definition there will not be interactions with other pathways that do other things We re not there yet, Armen conceded It is my strong conviction that we will be there in the next five to 10 years Logically then, he said, the FDA could base its approval on trials that involved as few as 10 or a dozen people, or on fewer trials.

Note that the <textarea> tag is one of the few form tags that has an open and a close tag. If you want the eld to have default content, the content should be placed between the tags. For example, the following code results in the initial form shown in Figure 13-3:

4. Once you ve made the first groove on all shapes, remove the paper pattern. Use your knife to go back over all of the cuts and make them a little deeper. Since the existing groove is guiding the knife, you can press a little harder this time. A few deep cuts over everything is fine, but the deeper you make the grooves, the easier the next steps will be. 5. Now, with all the shapes grooved at least twice (if not more), you can snap the main shape out of the plastic. Do this by bending the plastic backward, away from the colored front, along the grooved edges, with the groove on the outside of the bend. Pretend it s a sheet of paper you re trying to fold in half along the groove. Once it folds a certain amount, the weakened grooved portion will break. 6. Now you can remove the screen portion. Do this the same way that you removed the main shape, but only bend the edges of the screen backward until you can see a slight line appear on the back of the plastic. This line shows where the edge is. Make a few grooves along the line on the back of the plastic, and then bend the edge again. It should snap open in the middle. Repeat for each of the other four sides of the screen hole.

122 W

Conveniently, of course, basing approvals on smaller trials would make drug development a lot more feasible for a new biotech like, say, Antigenics that could not afford large trials Testing the limits of what the FDA will allow, two small biotech companies in the spring of 2004 submitted separate applications for cancer drugs with only minimal or fuzzy results In one case, trial data seemed to show that the drug Genasense, when taken in conjunction with a chemotherapy treatment, typically delayed the worsening of skin cancer by less than a month In the other case, a still-unnamed drug that was supposed to make radiation therapy more effective did not improve survival.